Patient Condition
Mutação PRNP D178N (129M / V heterozigoto), avó diagnosticada com FFI. Insônia progressiva por 4 meses, acompanhada de ataques de pânico, alucinações e perda de peso de 8 kg.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 65分钟/24h，频繁RBD事件（每周>10次），恐慌发作每日2-3次 |
|---|
| after | TST改善至110分钟/24h，RBD事件减少至每周2-3次，恐慌发作减少至每周1-2次 |
|---|
| highlight | 氟伏沙明联合氯硝西泮有效控制了RBD症状和恐慌发作，睡眠环境改造和光照疗法进一步优化了睡眠节律 |
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