Patient Condition
Mutación PRNP D178N (129M / V heterozigoto), abuela diagnosticada con FFI. Insomnio progresivo durante 4 meses, acompañado de ataques de pánico, alucinaciones y pérdida de peso de 8 kg.
Treatment Timeline
| Phase | Details | Date |
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 65分钟/24h,频繁RBD事件(每周>10次),恐慌发作每日2-3次 |
|---|
| after | TST改善至110分钟/24h,RBD事件减少至每周2-3次,恐慌发作减少至每周1-2次 |
|---|
| highlight | 氟伏沙明联合氯硝西泮有效控制了RBD症状和恐慌发作,睡眠环境改造和光照疗法进一步优化了睡眠节律 |