Patient Condition
Mutación PRNP D178N (129M homozigótico), 2 casos de FFI en familia. Insomnio progresivo durante 5 meses, acompañado de depresión severa, pérdida de peso de 10 kg y disfunción sexual.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 60分钟/24h，睡眠效率8%，HAMD 28分，体重下降10kg |
|---|
| after | TST改善至135分钟/24h，睡眠效率提升至15%，HAMD降至16分，情绪明显改善 |
|---|
| highlight | 氟伏沙明通过5-HT2A拮抗机制显著改善了睡眠质量，结合光照疗法和认知行为干预，抑郁症状明显缓解 |
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