Idiopathic Pulmonary Fibrosis (IPF)
Patient Condition
The patient was presented with progressive shortness of breath and dry cough, and had a history of smoking (15 pack-years). HRCT showed honeycomb lungs and grid shadows in both lungs. Lung function: FVC 58% predicted, DLCO 42% predicted. 6MWD 340m, mMRC score 2. IPF was diagnosed (GAP score of 4, stage II). Complicated with obstructive sleep apnea.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| integrated assessment | ||
| Combination therapy initiated | ||
| Combination therapy + pulmonary rehabilitation (months 1-12) | ||
| Maintenance treatment (Months 13-24) |
Treatment Outcome
| before | FVC accounted for 58% of predicted value, DLCO accounted for 42% of predicted value, 6MWD 340m, mMRC score 2, combined with OSA |
|---|---|
| after | After 24 months of treatment, FVC accounted for 54% of the predicted value (annual decline rate of approximately 2%), DLCO accounted for 38% of the predicted value, 6MWD 400m (improvement of 60m), and mMRC score dropped to level 1 |
| highlight | Combined treatment with Nitrib +NAC combined with CPAP and systemic lung rehabilitation improved 6MWD by 60 meters, mMRC score dropped from level 2 to level 1, and the effect of multidisciplinary comprehensive management was excellent. |