Patient Condition
The patient carries the PRNP gene D178N mutation (129M homozygous), with 3 cases of FFI in the family. Chief complaint: progressive insomnia for 6 months, accompanied by autonomic dysfunction (tachycardia, hypertension, hyperhidrosis), and ataxic gait.
Treatment Timeline
| Phase | Details | Date |
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| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 48 minutes/24h, CASS score 12 points, MMSE 22 points, unable to walk independently |
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| after | TST improved to 120 minutes/24 hours (under medication), autonomic symptoms were partially controlled, and survival was extended to 18 months |
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| highlight | Through the management of a multidisciplinary palliative care team, the patient's painful symptoms were effectively alleviated and the quality of life in the end-stage was improved. The overall survival period reached 18 months. |
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