Huntington's Disease (HD)
Patient Condition
Middle-advanced Huntington's disease, CAG repetition number 51, severe chore-like exercise, moderate to severe decline in cognition, severe insomnia and anxiety. UHDRS TMS 46 points, TFC 5 points, and MoCA 13 points.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| integrated assessment | ||
| Symptomatic medication + sleep management | ||
| Optimization of comprehensive symptomatic treatment | ||
| Long-term maintenance management |
Treatment Outcome
| before | UHDRS TMS 46, TFC 5, MoCA 13, severe choreo-like exercise, moderate to severe decline in cognition, severe insomnia and anxiety |
|---|---|
| after | UHDRS TMS dropped to 32 points (14 points improvement), TFC increased to 7 points (2 points improvement), MoCA increased to 15 points, motor symptoms reduced, and sleep improved |
| highlight | Tetrabenazine combined with sleep management effectively improves exercise and sleep symptoms, and comprehensive symptomatic treatment improves quality of life. |