Huntington's Disease (HD)
Patient Condition
Middle-advanced Huntington's disease, CAG repetition number 47, severe chore-like movement, moderate cognitive decline, irritability and aggressive behavior. UHDRS TMS 45 points, TFC 7 points, MoCA 16 points.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| integrated assessment | ||
| Drug symptomatic treatment + behavioral management | ||
| Optimization of comprehensive symptomatic treatment | ||
| Long-term maintenance management |
Treatment Outcome
| before | UHDRS TMS 45, TFC 7, MoCA 16, severe choreo-like exercise, moderate cognitive decline, aggressive behavior |
|---|---|
| after | UHDRS TMS dropped to 31 points (14 points improvement), TFC increased to 9 points (2 points improvement), MoCA improved to 18 points, motor and psychiatric symptoms improved |
| highlight | Tetrabenazine combined with quetiapine effectively controls exercise and aggressive behavior, and behavioral intervention treatment improves social function |