Huntington's Disease (HD)
Patient Condition
Middle-early Huntington's disease, CAG repetition number 43, moderate chorelike involuntary movements, mild decline in cognitive function (attention, executive function), and mild depression. UHDRS TMS 32 points, TFC 10 points, MoCA score 20 points.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| integrated assessment | ||
| Medication initiation + rehabilitation training | ||
| Drug optimization + comprehensive rehabilitation | ||
| Maintenance treatment and long-term management |
Treatment Outcome
| before | UHDRS TMS 32, TFC 10, MoCA 20, moderate choreo-like exercise, cognitive decline, mild depression |
|---|---|
| after | UHDRS TMS dropped to 18 points (improvement of 14 points), TFC increased to 12 points (improvement of 2 points), MoCA improved to 23 points, choreo-like movements were significantly reduced, and cognition and emotion improved |
| highlight | Deutrabenazine combined with comprehensive rehabilitation training significantly improves motor and cognitive function, with good drug tolerance |