Huntington's Disease (HD)
Patient Condition
Early Huntington's disease, CAG repetition number is 47, dance-like movements are mainly on the face and upper limbs, mild anxiety and sleep disorders, and MoCA score is 25 points. UHDRS TMS 17 points, TFC 12 points. My mother was diagnosed with HD.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| HD specialist assessment and CAG duplication confirmation | ||
| Tominersen (antisense oligonucleotide) intrathecal injection treatment | ||
| Joint rehabilitation training + behavioral management | ||
| Maintenance treatment and functional protection |
Treatment Outcome
| before | UHDRS TMS 17, TFC 12, MoCA 25, facial and upper limbs dance-like movements, anxiety and sleep disorders |
|---|---|
| after | UHDRS TMS dropped to 9 points (8 points improvement), TFC increased to 13 points (1 point improvement), MoCA maintained at 25 points, motor symptoms were significantly reduced, and sleep improved |
| highlight | Tominersen combined with sleep management effectively improves exercise symptoms and quality of life, and the effect of early intervention is stable. |