Glioblastoma Multiforme (GBM)
Patient Condition
The patient was 52 years old and developed headache, nausea, and gradually developed left limb weakness. MRI showed a mass occupying in the right frontal lobe, which showed irregular circular enhancement on enhanced scan, central necrosis, and large surrounding edema. Surgical resection and pathology were confirmed as glioblastoma (GBM, WHO grade IV), IDH wild type, and MGMT promoter unmethylated. At the time of diagnosis, the KPS score was 70 points 2 weeks after surgery. The recurrence occurred 6 months after the standard Stupp regimen (surgery + temozolomide concurrent chemoradiotherapy), and MRI showed new enhanced lesions around the surgical area.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| Recurrence assessment and precise treatment plan formulation | ||
| Tumor Electric Field Therapy + Immunotherapy Start | ||
| Personalized tumor vaccination | ||
| Long-term maintenance and follow-up |
Treatment Outcome
| before | Recurrence 6 months after GBM, IDH wild type, MGMT unmethylated, very poor prognosis (median survival <6 months), KPS 70 points |
|---|---|
| after | 24 months after recurrence, the patient was still alive and the condition was stable, the focus shrank by 30%, KPS was 90, normal work was restored, and the survival period was significantly prolonged |
| highlight | Combination treatment with TTF+ immunotherapy + personalized tumor vaccine significantly extends the survival of patients with recurrent GBM, breaking expectations of rapid progression of recurrent GBM |