Patient Condition
PRNP D178N mutation (129M homozygous), mother and uncle both died of FFI. Progressive insomnia for 9 months, accompanied by severe autonomic dysfunction (orthostatic hypotension, anhidrosis, constipation), and depression.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 40 minutes/24 hours, CASS 15 points, severe orthostatic hypotension (supine and upright blood pressure difference>40mmHg) |
|---|
| after | TST improved to 105 min/24h, CASS improved to 11 points, orthostatic hypotension improved (supine standing blood pressure difference <25mmHg) |
|---|
| highlight | Fluvoxamine combined with autonomic nerve function management effectively improves sleep and cardiovascular autonomic nerve regulation, and comprehensive sleep management further improves quality of life. |
|---|