Patient Condition
PRNP D178N mutation (129M homozygous), father died of FFI. Progressive insomnia for 6 months, accompanied by severe daytime sleepiness (but unable to sleep at night), nightmares, and weight loss of 11kg.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 50 minutes/24 hours, contradictory sleep pattern, MoCA 21 points, weight loss 11kg |
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| after | TST improved to 120 minutes/24 hours, sleep rhythm partially recovered, MoCA stabilized at 20 points, and weight loss stopped |
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| highlight | Fluvoxamine combined with L-tryptophan and strong light therapy effectively rebuilt part of the sleep rhythm and slowed down cognitive function decline |
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