Patient Condition
PRNP D178N mutation (129M/V heterozygous), grandmother diagnosed with FFI. Progressive insomnia for 4 months, accompanied by panic attacks, hallucinations, and weight loss of 8kg.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 65 minutes/24 hours, frequent RBD events (>10 per week), panic attacks 2-3 times a day |
|---|
| after | TST improved to 110 minutes/24h, RBD events reduced to 2-3 times per week, and panic attacks reduced to 1-2 times per week |
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| highlight | Fluvoxamine combined with clonazepam effectively controlled RBD symptoms and panic attacks, and sleep environment modification and light therapy further optimized sleep rhythm |
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