Patient Condition
PRNP D178N mutation (129M homozygous), 2 FFI cases in family. Progressive insomnia for 5 months, accompanied by severe depression, weight loss of 10kg, and sexual dysfunction.
Treatment Timeline
| Phase | Details | Date |
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| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 60 minutes/24 hours, sleep efficiency 8%, HAMD 28 points, weight loss 10kg |
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| after | TST improved to 135 minutes/24 hours, sleep efficiency increased to 15%, HAMD dropped to 16 points, and mood improved significantly |
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| highlight | Fluvoxamine significantly improved sleep quality through the 5-HT2A antagonism mechanism. Combined with light therapy and cognitive behavioral intervention, depressive symptoms were significantly relieved. |
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