Patient Condition
PRNP gene D178N mutation (129M homozygous), grandfather with suspected FFI history. Progressive insomnia for 7 months, accompanied by sudden weight loss of 15kg, impotence, and anisocoria.
Treatment Timeline
| Phase | Details | Date |
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| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 42 minutes/24 hours, weight drop 15kg, frequent aggressive attacks, MMSE 20 points |
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| after | TST improved to 95 minutes/24 hours, aggressive attacks reduced by 80%, weight stabilized, and nutritional status improved |
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| highlight | Comprehensive management at top neurology centers in China has effectively controlled behavioral and mental symptoms, and palliative treatment has significantly improved patients 'quality of life in the end stages of life |
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