Patient Condition
The patient developed weakness in both lower limbs since the age of 63, and was diagnosed with ALS (limb onset) at the age of 64. At the time of diagnosis, ALSFRS-R was 28, FVC was 60%, and both lower limb muscle strength was grade 3. Progress is rapid (monthly decrease of 1.2 points). Edaravone could not be used due to financial reasons and a comprehensive supportive treatment plan was selected.
Treatment Timeline
| Phase | Details | Date |
|---|
| Comprehensive evaluation and Ziluzole launch | | |
| Nutrition optimization and rehabilitation training | | |
| Long-term comprehensive management | | |
Treatment Outcome
| before | ALSFRS-R 28 points, monthly drop 1.2 points, FVC 60%, financial constraints cannot use Edaravone |
|---|
| after | ALSFRS-R 23 points, a 2-year decrease of 5 points (delay of 79%), FVC 52%(BiPAP), significant improvement in comprehensive management |
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| highlight | Comprehensive supportive treatment (Ziluzole +BiPAP+PEG+ rehabilitation) delays progress by 79%, a cost-effective solution |
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