Patient Condition
The patient developed right lower limb weakness and abnormal gait since the age of 48, and was diagnosed with ALS (limb onset type) at the age of 49. At the time of diagnosis, ALSFRS-R was 36, FVC was 80%, and right lower limb muscle strength was grade 3+. The progress rate is moderate (0.6 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|
| Combination therapy initiated | | |
| ongoing treatment for | | |
| maintenance treatment | | |
Treatment Outcome
| before | ALSFRS-R 36 points, monthly drop 0.6 points, FVC 80%, right lower limb muscle strength grade 3+ |
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| after | ALSFRS-R 31 points, decrease by 5 points (delay by 72%) at 30 months, FVC 71%, and still walk independently |
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| highlight | Combination treatment delayed progress by 72% after 30 months, and patients maintained independent walking and daily living abilities |
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