Patient Condition
The patient developed hands weakness and muscle atrophy at the age of 57, and was diagnosed with ALS (limb onset) at the age of 58. At the time of diagnosis, ALSFRS-R was 34, FVC was 74%, and the grip strength of both hands decreased. The progress rate is moderate (0.9 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|
| Diagnosis and evaluation of bulbar onset ALS | | |
| AMX0035 combination therapy + edaravone | | |
| Swallow rehabilitation + nutrition management + stem cell therapy | | |
| Long-term maintenance and multidisciplinary management | | |
Treatment Outcome
| before | ALSFRS-R 34, monthly decrease of 0.9, FVC 74%, hand strength decreased |
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| after | ALSFRS-R 29 points, 2-year decrease of 5 points (72% delay), FVC 65% |
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| highlight | Combination therapy delayed progression by 72%, and achieved significant functional preservation in Australia patients |
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