Patient Condition
The patient developed hands weakness and muscle fasciculation at the age of 53, and was diagnosed with ALS (limb onset) at the age of 54. At the time of diagnosis, ALSFRS-R was 35, FVC was 76%, and the grip strength of both hands decreased. The progress rate is moderate (0.8 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|
| Combination therapy initiated | | |
| Continuous treatment and evaluation | | |
| long-term maintenance | | |
Treatment Outcome
| before | ALSFRS-R 35, monthly decrease of 0.8, FVC 76%, hand strength decreased |
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| after | ALSFRS-R 30 points, 2-year decrease of 5 points (74% delay), FVC 68%, ability to daily activities maintained |
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| highlight | Combination therapy delayed progression by 74%, and patients maintained high functional independence after 24 months |
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