Patient Condition
The patient developed weakness and muscle atrophy in the right lower limb since the age of 45, and was diagnosed with ALS (limb onset type) at the age of 46. At the time of diagnosis, ALSFRS-R was 37, FVC was 82%, and right lower limb muscle strength was grade 4. No family history. The progress rate is moderate (0.7 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|
| Combination therapy initiated | | |
| Continuous treatment and rehabilitation | | |
| long-term maintenance | | |
Treatment Outcome
| before | ALSFRS-R 37 points, monthly drop 0.7 points, FVC 82%, right lower limb muscle strength grade 4 |
|---|
| after | ALSFRS-R 32 points, a decrease of 5 points at 30 months (76% delay), FVC 74%, independent walking ability maintained |
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| highlight | Combination treatment delayed progress by 76%, and young and middle-aged ALS patients still maintained the ability to walk independently after 30 months |
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