Patient Condition
The patient developed dysarthria and dysphagia at the age of 61, and was diagnosed with ALS (bulbar onset type) at the age of 62. At the time of diagnosis, ALSFRS-R was 32, FVC was 75%, and swallowing function was impaired (abnormal drinking water test). The prognosis of bulbar onset type is poor and the progress rate is rapid (monthly drop of 1.2 points).
Treatment Timeline
| Phase | Details | Date |
|---|
| Combination treatment and swallowing rehabilitation | | |
| Strengthen treatment and nutritional management | | |
| Long-term maintenance and respiratory management | | |
Treatment Outcome
| before | ALSFRS-R 32 points, monthly drop 1.2 points, FVC 75%, and poor prognosis for bulbar onset |
|---|
| after | ALSFRS-R 25 points, 2-year decrease of 7 points (76% delay), FVC 60%, good quality of life with PEG+BiPAP support |
|---|
| highlight | Patients with bulb-onset ALS treated with combination treatment + early nutritional intervention delayed progress by 76%, significantly improved prognosis |
|---|