Amyotrophic Lateral Sclerosis (ALS)
Patient Condition
The patient developed hands weakness and muscle atrophy since the age of 56. At the age of 57, ALS (limb onset type, El Escorial diagnosis level) was diagnosed. At the time of diagnosis, ALSFRS-R was 34, FVC was 72%, and the grip strength of both hands was significantly reduced. Progress is rapid (monthly decrease of 1.0 points). He had a previous history of hypertension.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| Combination therapy initiated | ||
| Triple treatment and monitoring | ||
| Maintenance treatment and respiratory support |
Treatment Outcome
| before | ALSFRS-R 34 points, monthly drop 1.0 points, FVC 72%, and hand strength decreased significantly |
|---|---|
| after | ALSFRS-R 28 points, 2-year decrease of 6 points (delay of 75%), FVC 62%(BiPAP support), significantly delayed progression |
| highlight | The triple regimen of Ziluzole +Edaravone+ AMX0035 delayed progression by 75%, and achieved significant functional preservation in patients with rapidly progressive ALS |