Amyotrophic Lateral Sclerosis (ALS)
Patient Condition
The patient developed left lower limb weakness and unstable gait since the age of 43. At the age of 44, ALS (limb onset type) was diagnosed. At the time of diagnosis, ALSFRS-R was 38, FVC was 85%, and left lower limb muscle strength was grade 4. No family history, and negative for SOD1/other genes. Progress is slow (0.5 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| Early combination therapy initiated | ||
| Continuous treatment and functional optimization | ||
| long-term maintenance treatment |
Treatment Outcome
| before | ALSFRS-R 38 points, monthly drop 0.5 points, FVC 85%, left lower limb muscle strength grade 4 |
|---|---|
| after | ALSFRS-R 33 points, a decrease of 5 points at 30 months (67% delay), FVC 78%, independent activity maintained |
| highlight | Early initiation of combination therapy delayed progress by 67%, maintaining high functional levels and quality of life after 30 months |