Amyotrophic Lateral Sclerosis (ALS)
Patient Condition
The patient developed right hand weakness and muscle beating since the age of 50, and was diagnosed with ALS (El Escorial diagnosed level) at the age of 51. On arrival, the ALSFRS-R score was 36 points, FVC was 78%, right upper limb muscle strength was grade 3, and EMG showed extensive neurogenic damage. The course of disease is about 1 year, with limb onset, and the progression rate is moderate (ALSFRS-R decrease of 0.8 points per month).
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| Combination medication initiation and evaluation | ||
| Standardize treatment and functional monitoring | ||
| Long-term maintenance and complication management |
Treatment Outcome
| before | ALSFRS-R 36 points, monthly drop 0.8 points, FVC 78%, right upper limb muscle strength grade 3 |
|---|---|
| after | ALSFRS-R 31 points, 2-year decrease of 5 points (delay of 69%), FVC 70%, and can still walk independently |
| highlight | Combination treatment with Ziluzole +Edaravone delayed the progression of ALS by 69%, and the patient still maintained the ability to walk independently after 24 months |