Patient Condition
Retired university professors began to experience language expression difficulties and a declining sense of direction at the end of 2022. He was admitted to the Affiliated Hospital of the University of Tokyo School of Medicine, with an MMSE score of 20 points and a CDR score of 0.5. CSF biomarkers were consistent with the diagnosis of AD. MRI showed mild hippocampal atrophy.
Treatment Timeline
| Phase | Details | Date |
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| Comprehensive multidimensional AD assessment | | |
| Lecanemab cautious initiation with ARIA management | | |
| Combined cognitive rehabilitation + non-pharmacological interventions | | |
| Maintenance therapy and functional preservation | | |
Treatment Outcome
| before | MMSE score 20 points, language expression difficulties, decreased sense of direction, mild impairment of daily living ability |
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| after | MMSE score of 24 points (improvement of 4 points), improved language fluency, improved sense of direction, and ability to complete daily activities independently |
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| highlight | Language function has been significantly improved and quality of life has been significantly improved |
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