Patient Condition
The 39-year-old patient presented with headache and left limb weakness. MRI showed enhanced occupying mass in the right temporal lobe. Surgical resection was diagnosed with glioblastoma (GBM, WHO grade IV), IDH wild-type, and MGMT promoter unmethylated. The recurrence occurred 8 months after 6 cycles of standard Stupp regimen (radiotherapy + temozolomide) after surgery. The ECOG score was 2 at the time of diagnosis, and the MRI showed a recurrent tumor of 3.2 cm.
Treatment Timeline
| Phase | Details | Date |
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| Secondary surgery and precision medicine evaluation | | |
| EGFRvIII CAR-T + PD-1 combined immunotherapy | | |
| Maintenance immunotherapy and long-term follow-up | | |
Treatment Outcome
| before | GBM recurrence, failure of standard treatment, MGMT unmethylated (very poor prognosis), ECOG 2 |
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| after | Continuous CR (complete remission) 24 months after surgery, ECOG score 0, and returned to normal work |
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| highlight | EGFRvIII CAR-T combined with PD-1 achieves sustained complete remission of recurrent GBM and 24 months of disease-free survival |
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