Atrofia multipli-sistemica (MSA)
Patient Condition
MSA-C, progressive cerebellar ataxia for 14 months with orthostatic hypotension, constipation, and RBD. UMSARS-I 17, UMSARS-II 19, SCOPA-AUT 16. MRI showed middle cerebellar peduncle hyperintensity and pontine atrophy. Enrolled in IVIg therapy trial.
Treatment Timeline
| Phase | Details | Date |
|---|---|---|
| 入组评估 | ||
| IVIg免疫治疗 | ||
| 随访评估 |
Treatment Outcome
| before | UMSARS-I 17分，UMSARS-II 19分，脑脊液NfL 68pg/mL，IL-6升高 |
|---|---|
| after | UMSARS-I改善至15分，UMSARS-II改善至17分，脑脊液NfL降至50pg/mL（下降26%），IL-6恢复正常水平 |
| highlight | IVIg免疫调节治疗显著改善了运动功能和神经炎症指标，IL-6恢复正常提示免疫介导的神经保护机制有效 |