Patient Condition
mutazione PRNP D178N (129M omozigoto), padre morto di FFI. Insomnia progressiva per 6 mesi, accompagnata da sonnolenza diurna grave (ma incapace di dormire di notte), incubi e perdita di peso di 11 kg.
Treatment Timeline
| Phase | Details | Date |
|---|
| Symptom control and sleep induction | | |
| Immunomodulation and symptomatic treatment | | |
| Long-term maintenance and palliative care | | |
Treatment Outcome
| before | TST 50分钟/24h，矛盾性睡眠模式，MoCA 21分，体重下降11kg |
|---|
| after | TST改善至120分钟/24h，睡眠节律部分恢复，MoCA稳定在20分，体重停止下降 |
|---|
| highlight | 氟伏沙明联合左旋色氨酸和强光照疗法有效重建了部分睡眠节律，认知功能下降速度减缓 |
|---|