Celiac Disease.
Summary
Murray JA(1), Husby S(2). Review Article Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA antibodies against tissue transglutaminase, and may include tests to confirm the presence of endomysial antibodies or even duodenal biopsies, although the latter are becoming less necessary. The presence of genes encoding HLA-DQ2 or HLA-DQ8 is a prerequisit
Content
# Murray JA(1), Husby S(2).
*Review Article*
Celiac disease, a common autoimmune condition affecting approximately 1% of the
population, can develop with exposure to gluten at any age. Diagnosis involves
serologic testing, especially for IgA antibodies against tissue
transglutaminase, and may include tests to confirm the presence of endomysial
antibodies or even duodenal biopsies, although the latter are becoming less
necessary. The presence of genes encoding HLA-DQ2 or HLA-DQ8 is a prerequisite
for the disease. A gluten-free diet is the mainstay of treatment, but some
adults have nonresponsive celiac disease, which warrants closer monitoring
because of an increased risk of malignant conditions. Celiac disease also
frequently co-occurs with other autoimmune disorders, such as type 1 diabetes
mellitus and autoimmune thyroid disease.
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DOI: 10.1056/NEJMcp2415548