News & Updates
Stay informed with the latest news on rare diseases, innovative treatments, and medical research.
Oral small-molecule GLP-1 receptor agonist for type 2 diabetes and obesity.
Oral small-molecule GLP-1 receptor agonist for type 2 diabetes and obesity The Lancet 2025 Comment Oral small-molecule GLP-1 receptor agonist for type...
Darfur's humanitarian emergency: a call for immediate action.
Darfur's humanitarian emergency: a call for immediate action The Lancet 2025 Correspondence Darfur’s humanitarian more than 460 patients and their 3 R...
Preoperative mFOLFIRINOX versus PAXG for stage I-III resectable and borderline resectable pancreatic ductal adenocarcinoma (PACT-21 CASSANDRA): results of the first randomisation analysis of a randomised, open-label, 2 × 2 factorial phase 3 trial.
Preoperative mFOLFIRINOX versus PAXG for stage I–III resectable and borderline resectable pancreatic ductal adenocarcinoma (PACT-21 CASSANDRA): result...
Comparison of inhalational methoxyflurane, intranasal fentanyl, and intravenous morphine for treatment of prehospital acute pain in Norway (PreMeFen): a randomised, non-inferiority, three-arm, phase 3 trial.
Comparison of inhalational methoxyflurane, intranasal fentanyl, and intravenous morphine for treatment of prehospital acute pain in Norway (PreMeFen):...
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial.
Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double...
Exploring CAR NK-cell therapy for refractory lupus.
Exploring CAR NK-cell therapy for refractory lupus The Lancet 2025 Comment Research Projects Agency Triage Challenge; and has received equipment 4 And...
Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China.
Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China The Lancet 2025 Articles Efficacy a...
Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy?
Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy? The Lancet 2025 Hypothesis Amylin and the renin-angiotensin syst...
Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia
Zanidatamab with and without Tislelizumab in HER2-Positive Gastroesophageal
Zanidatamab with and without Tislelizumab in HER2-Positive Gastroesophageal Original Article Abstract Background Zanidatamab, a dual human epiderma...
Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure.
Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure. Original Article Abstract Background Biologic ventricular assist tissue (Bio...
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Original Article Abstract Background Whether anticoagulation alone is an...
Leishmaniasis.
Aronson NE(1), Musa AM(2), Satoskar AR(3)(4). Review Article Leishmaniases comprise clinically distinct diseases caused by the protozoan parasite lei...
Combating small extracellular vesicle-mediated immunological barriers in the tumor microenvironment via strategically activatable PEGylated peptides
Tumor cell-derived small extracellular vesicles (TDEs) play a critical role in immune evasion, including the establishment of an immunosuppressive tu...
Phosphoproteomics distinguishes disease-specific mechanisms for human phospholamban cardiomyopathy reversible by RNA therapy
Phospholamban (PLN) p.Arg14del (R14Δ/+, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves card...
Head and Neck Cancer
Adverse Effects and Treatment Discontinuation of Blood Pressure-Lowering Drugs and Combinations: A Network Meta-Analysis. Wang N(1), Van Der Hoorn S(1...
PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis
Psoriasis is a common immune-mediated skin disease driven largely by interleukin-17A (IL-17A). Although IL-17A plays a key role in disease pathogene...
Farnesylation-driven KRAS phase separation promotes colon tumor growth
Kirsten Rat Sarcoma viral oncogene homolog (KRAS) is one of the most frequently activated driver genes across human cancers. We identified a regulato...
Structural basis of Wnt signalosome extracellular complex assembly
Recognition of Wnt proteins by Frizzled (Fzd) receptors and the low-density lipoprotein receptor-related protein 5/6 (LRP5/6) co-receptor is essentia...
Uncovering spatially resolved functional genomics with CRISPR screen sequencing
Spatial omics has advanced our understanding of tissue-level biology, yet tools to systematically link gene functional perturbations to spatial pheno...
TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy
Detection of α-synuclein (α-syn) amyloid seeds in human biofluids has attracted great interest for clinical diagnosis of synucleinopathies. However, ...
Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial
While most gastrointestinal stromal tumors are driven by oncogenic mutations in KIT or PDGFRA, 10-15% exhibit functional loss of the succinate dehydr...
LISS enables immune evasion of colorectal cancers irrespective of MSI status
Despite being hailed as a significant advancement in cancer treatment, immune checkpoint blockade (ICB) has not yielded favorable outcomes in colorec...
Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery: Research Summary
Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery: The EMMA-Can Randomized Clinical Trial. Shankar JJS(1...
Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery: The EMMA-Can Randomized Clinical Trial
The Veterans Affairs' Whole Health Approach for Chronic Pain Management: The wHOPE Randomized Clinical Trial. Seal KH(1)(2)(3)(4), Morasco BJ(5), Mart...
Spinal Manipulation and Biopsychosocial Self-Management for Back Pain
Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial. Banerjee R(1), Komarow L(2), Li Y(2), Mau ...
Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis
Fructose consumption increases the risk of obesity-related metabolic diseases and some cancers, but its role in hepatocellular carcinogenesis (HCC) r...
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia.
In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia. Original Article Abstract Background Persons carrying loss-of-function varia...
An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma
Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, breast, and pancreatic cancer. In glioblastoma (GB),...
Updated trends in the global prevalence and burden of mental disorders,
Updated trends in the global prevalence and burden of mental disorders, Original Article Background The 2023 iteration of the Global Burden of Diseas...
Platelets must not be overlooked in civilian and military blood preparedness.
Platelets must not be overlooked in civilian and military blood preparedness. Review Article Platelets must not be overlooked in civilian and military...
Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double-blind, placebo-controlled, phase 2b and 3 trials.
Epub 2026 May 18. Original Article Background Interleukin-33 and its receptor, ST2, are implicated in neutrophilic and eosinophilic inflammation dur...
Astegolimab and the new era of biologics in COPD care.
Epub 2026 May 18. Review Article Astegolimab and the new era of biologics in COPD care. Leung C(1), Sin DD(2). Author information: (1)Division of Resp...
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication.
Epub 2026 May 7. Original Article Background Patients with extensive ischaemic change are often excluded from endovascular thrombectomy. We aimed to...
The in vivo revolution in CAR-T therapy medicinal products: challenges and regulatory prospects
Chimeric antigen receptor T-cell (CAR-T) therapy, a groundbreaking advancement in cancer immunotherapy, has demonstrated remarkable efficacy in treat...
Fulvestrant versus capecitabine as maintenance therapy in hormone receptor-positive, HER2-negative metastatic breast cancer after first-line chemotherapy (FAMILY): a multicenter, open-label, randomized, phase 3 trial
Maintenance therapy is key in prolonging remission and improving quality of life for hormone receptor-positive (HR + ), HER-2 negative (HER2-) metast...
AI-induced never-skilling in medical education
AI-induced never-skilling in medical education - Nat Med 2026
Resetting autoimmune disease with CAR cell therapies
Pathogenic B cell activation underlies many autoimmune diseases (AIDs), and their depletion is an attractive therapeutic approach. Chimeric antigen r...
Taking plant membrane temperatures
Science. 2026 May 21;392(6800):885-890. doi: 10.1126/science.aeb1752. Plasma membrane nanoclusters help plants distinguish growth-promoting warmth fr...
Tracking human mobility for wildlife conservation
Science. 2026 May 21;392(6800):879-884. doi: 10.1126/science.adq3396. Human mobility data expand ecological analyses of people's impact on wild anima...
An appetite for protein
Science. 2026 May 21;392(6800):eadv3355. doi: 10.1126/science.adv3355. The fly gut integrates nutrient-specific appetite control.
The oscillatory biology of sleep: Linkage to dementia
During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity in...
Reward magnitude determines reinforcement learning efficiency
Standard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how rewar...
Progression without progress
Progress in the use of artificial intelligence (AI) to advance scientific discovery has made it increasingly realistic to envision automated "end-to-...
Complex interplay of neuronal and hormonal gut-brain responses to essential amino acid deficit
A deficit in dietary protein elicits a nutrient-specific appetite, yet the underlying mechanisms remain poorly understood. In this work, we identify ...
Magnon hydrodynamics in an atomically thin ferromagnet
Strong interactions between particles can lead to emergent collective excitations. Spin waves, known as magnons, have been predicted to reach a stro...
Dynamics of disordered quantum systems with two- and three-dimensional tensor networks
Large-scale quantum annealing dynamics of Ising spin glasses were recently implemented on D-Wave's Advantage2 system on a range of lattices. After e...
A relay energy transfer paradigm for asymmetric photocatalyzed [4+2] cycloadditions
In asymmetric energy transfer photocatalysis, direct incorporation of conventional chiral catalysts has achieved satisfactory enantiocontrol in seve...
FERONIA orchestrates plasma membrane nanoclusters for plant thermotolerance
Climate warming poses increasing thermal challenges to plants, yet how plasma membrane biophysics contributes to heat adaptation remains poorly under...
Role of tectonic rock damage in erosional processes: A global analysis
The role of active faults in driving rock uplift is well known, but their influence on rock damage and erosional efficiency remains unclear globally....