End-stage liver cirrhosis with liver failure
About
End-stage liver failure is the final stage of the development of various chronic liver diseases (viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, etc.). The liver structure is replaced by fibrous tissue, forming false lobules, and liver function is severely damaged. Core dilemmas: ① Complications caused by end-stage liver failure (hepatic encephalopathy, esophageal and gastric varices rupture and bleeding, hepatorenal syndrome, spontaneous peritonitis) are themselves independent fatal factors;② Medical treatment can only temporarily relieve symptoms and cannot reverse liver cirrhosis;③ Liver transplantation is the only radical cure, but donors are scarce.
Features & Symptoms
- The liver structure is completely destroyed
- Loss of metabolism and detoxification functions
- Hepatic encephalopathy, upper gastrointestinal bleeding
- refractory ascites
Treatment Options
| Treatment | Description | Stage | Price Range |
|---|---|---|---|
| Liver xenotransplantation (pig liver) | Genetically modified pig liver transplantation has completed the world's first human trial in 2024 (University of Maryland). Provide new treatment options for patients with end-stage liver failure. | 临床试验 | $600K - $2M/次 |
| Urgent cross-border liver matching | Global liver source database matching + surgical destination coordination + postoperative management. Use the International Liver Source Network to find suitable donors for patients in urgent need of transplantation. | 临床应用 | $200K - $600K/次 |
| artificial liver support system | Molecular adsorbent recirculation system (MARS) or plasma exchange, as bridging therapy before liver transplantation. | 临床应用 | $50K - $150K/疗程 |
Prognosis
For those who have not received a liver transplant, the survival period usually does not exceed 6 months
Additional Notes
Notes: MELD score: A MELD score of>15 is recommended to evaluate liver transplantation, and a MELD score of>20 should be given priority; Complications prevention: Esophageal and gastric variceal bleeding is one of the main causes of death, and regular endoscopy and prophylactic use of non-selective beta blockers are recommended; Hepatic encephalopathy management: Lactulose and rifaximin can prevent and treat hepatic encephalopathy; Infection prevention: Spontaneous bacterial peritonitis is common, and antibiotics should be used preventively in patients with ascites; Coagulation management: Vitamin K deficiency and coagulation factor synthesis disorders are common, requiring regular monitoring of INR and vitamin K supplementation. Exclusive service commitment: The platform will allocate a dedicated medical team to each patient to assist in dismantling and properly deploying the following precautions throughout the process. When cross-state and cross-border diagnosis and treatment projects or drugs are involved, the platform will make overall arrangements for the entire docking; for disabled and semi-disabled patient groups, the platform will provide rush-free alternative solutions (including remote consultation, door-to-door sampling, direct drug delivery in the cold chain, etc.), to ensure that patients can get the same high-quality diagnosis and treatment resources without having to travel in person.; Research phase: Clinical trial. Outcome: For those who have not received liver transplantation, the survival period usually does not exceed 6 months.
Frequently Asked Questions
What is End-stage liver cirrhosis with liver failure?
End-stage liver failure is the final stage of the development of various chronic liver diseases (viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, etc.). The liver structure is replaced by fibrous tissue, forming false lobules, and liver function is severely damaged. Core dilemmas: ① Complications caused by end-stage liver failure (hepatic encephalopathy, esophageal and gastric varices rupture and bleeding, hepatorenal syndrome, spontaneous peritonitis) are themselves independent fatal factors;② Medical treatment can only temporarily relieve symptoms and cannot reverse liver cirrhosis;③ Liver transplantation is the only radical cure, but donors are scarce.
What are the symptoms of End-stage liver cirrhosis with liver failure?
The liver structure is completely destroyed,Loss of metabolism and detoxification functions,Hepatic encephalopathy, upper gastrointestinal bleeding,refractory ascites
How is End-stage liver cirrhosis with liver failure treated?
Liver xenotransplantation (pig liver): Genetically modified pig liver transplantation has completed the world's first human trial in 2024 (University of Maryland). Provide new treatment options for patients with end-stage liver failure.; Urgent cross-border liver matching: Global liver source database matching + surgical destination coordination + postoperative management. Use the International Liver Source Network to find suitable donors for patients in urgent need of transplantation.; artificial liver support system: Molecular adsorbent recirculation system (MARS) or plasma exchange, as bridging therapy before liver transplantation.
What is the prognosis for End-stage liver cirrhosis with liver failure?
For those who have not received a liver transplant, the survival period usually does not exceed 6 months