Glyceroneogenesis has a new PEP in its step(s)
Summary
Mitochondria generate phosphoenolpyruvate (PEP), although its export mechanism and physiological roles were unknown. In this issue of Cell, Kajimura and colleagues identify SLC25A35 as the mitochondrial PEP exporter and uncover a previously unrecognized role for mitochondrial PEP synthesis in glyceroneogenesis in adipose tissue and upon development of fatty liver disease.
Content
# Glyceroneogenesis has a new PEP in its step(s)
*Published: 2026 May 14*
Mitochondria generate phosphoenolpyruvate (PEP), although its export mechanism
and physiological roles were unknown. In this issue of Cell, Kajimura and
colleagues identify SLC25A35 as the mitochondrial PEP exporter and uncover a
previously unrecognized role for mitochondrial PEP synthesis in
glyceroneogenesis in adipose tissue and upon development of fatty liver disease.
DOI: 10.1016/j.cell.2026.04.035