CLIM-TIME links genetic cancer drivers to immune landscapes
Summary
Immunotherapy resistance is associated with immune-privileged microenvironments, yet the interacting role of tumor-intrinsic genetics remains unclear. In this issue of Cell, Wang et al. introduce CLIM-TIME, a spatially resolved in vivo CRISPR screening platform linking loss of tumor suppressor genes to distinct metastatic immune architectures and divergent responses to immunotherapy.
Content
# CLIM-TIME links genetic cancer drivers to immune landscapes
*Published: 2026 Mar 5*
Immunotherapy resistance is associated with immune-privileged microenvironments,
yet the interacting role of tumor-intrinsic genetics remains unclear. In this
issue of Cell, Wang et al. introduce CLIM-TIME, a spatially resolved in vivo
CRISPR screening platform linking loss of tumor suppressor genes to distinct
metastatic immune architectures and divergent responses to immunotherapy.
DOI: 10.1016/j.cell.2026.01.014