Cerebral Amyloid Angiopathy.
Summary
Cerebral Amyloid Angiopathy. Review Article Cerebral amyloid angiopathy is a major cause of hemorrhagic stroke, a frequent contributor to age-related cognitive impairment, and a key component in adverse responses to beta-amyloid (Aβ) immunotherapy. Defined by pathological deposition of Aβ in the small blood vessels of the brain, cerebral amyloid angiopathy is most often diagnosed on the basis of magnetic resonance imaging studies showing multiple hemorrhages or leptomeningeal blood products
Content
# Cerebral Amyloid Angiopathy.
*Review Article*
Cerebral amyloid angiopathy is a major cause of hemorrhagic stroke, a frequent
contributor to age-related cognitive impairment, and a key component in adverse
responses to beta-amyloid (Aβ) immunotherapy. Defined by pathological deposition
of Aβ in the small blood vessels of the brain, cerebral amyloid angiopathy is
most often diagnosed on the basis of magnetic resonance imaging studies showing
multiple hemorrhages or leptomeningeal blood products within or overlying the
cerebral cortex. The disorder typically manifests as hemorrhagic stroke or as a
contributing factor to cognitive decline and, less commonly, with transient
focal neurologic symptoms or a cerebral inflammatory autoimmune syndrome. The
high risk of recurrent hemorrhagic strokes associated with cerebral amyloid
angiopathy poses a particular challenge in patients with indications for
antithrombotic therapy and dictates a carefully individualized weighing of risks
and benefits. Ongoing research is focused on tools to aid in risk prediction,
early diagnostic markers, and identification of key pathogenic steps as targets
for disease-modifying therapies.
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DOI: 10.1056/NEJMra2411298