Inflammatory Myopathies.
Summary
Inflammatory Myopathies. Review Article Inflammatory myopathies are a heterogeneous group of autoimmune diseases characterized by immune-mediated damage to skeletal muscle. They are classified into five major subtypes: inclusion-body myositis, immune-mediated necrotizing myopathies, antisynthetase syndrome, overlapping myositis, and dermatomyositis, each with distinct clinical features and outcomes. Inclusion-body myositis and immune-mediated necrotizing myopathies primarily affect muscle,
Content
# Inflammatory Myopathies.
*Review Article*
Inflammatory myopathies are a heterogeneous group of autoimmune diseases
characterized by immune-mediated damage to skeletal muscle. They are classified
into five major subtypes: inclusion-body myositis, immune-mediated necrotizing
myopathies, antisynthetase syndrome, overlapping myositis, and dermatomyositis,
each with distinct clinical features and outcomes. Inclusion-body myositis and
immune-mediated necrotizing myopathies primarily affect muscle, with prognosis
largely determined by functional impairment, whereas antisynthetase syndrome,
overlapping myositis, and dermatomyositis are systemic diseases that can involve
the skin, joints, and lungs and may be life-threatening. The majority of
inflammatory myopathies are associated with myositis-specific autoantibodies,
which inform diagnosis, subtype classification, and prognosis. Advances in
understanding the distinct pathomechanisms underlying each subgroup now enable
increasingly targeted therapeutic approaches.
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DOI: 10.1056/NEJMra2415426