Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study
Summary
CONCLUSIONS Underestimation of the reduction in GFR by estimated GFR requires further investigation. Equations that included both creatinine and cystatin C more accurately monitored change in measured GFR than equations based on one biomarker. Increased use of combined biomarker equations in clinical practice could improve disease monitoring and potentially clinical care. STUDY REGISTRATION: ISRCTN registry ISRCTN42955626.
Content
# Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study
*Published: 2026 Mar 19*
## CONCLUSIONS
Underestimation of the reduction in GFR by estimated GFR requires
further investigation. Equations that included both creatinine and cystatin C
more accurately monitored change in measured GFR than equations based on one
biomarker. Increased use of combined biomarker equations in clinical practice
could improve disease monitoring and potentially clinical care.
STUDY REGISTRATION: ISRCTN registry ISRCTN42955626.
DOI: 10.1136/bmj-2025-085005