Alkylidene functionalization produces highly recyclable and scalable polyhydroxyalkanoates
Summary
Recyclable polymers that can be produced at scale and readily tuned within the same polymer framework for specific properties are critical to achieving a circular materials economy. To this end, synthetic poly(3-hydroxyalkanoate)s (PHAs) have emerged as high-performance, chemically recyclable variants of biological PHAs, but their difficult monomer syntheses and suboptimal recycling efficiencies pose challenges for large-scale deployment. In this study, we investigated a β-isopropylidene P
Content
# Alkylidene functionalization produces highly recyclable and scalable polyhydroxyalkanoates
*Published: 2026 May 7*
Recyclable polymers that can be produced at scale and readily tuned within the
same polymer framework for specific properties are critical to achieving a
circular materials economy. To this end, synthetic poly(3-hydroxyalkanoate)s
(PHAs) have emerged as high-performance, chemically recyclable variants of
biological PHAs, but their difficult monomer syntheses and suboptimal recycling
efficiencies pose challenges for large-scale deployment. In this study, we
investigated a β-isopropylidene PHA, i-PHA, for which the lactone monomer can be
synthesized by existing industrial methods from biomass-derived isobutyric acid.
The alkylidene substituent prevents decarboxylative degradation typically
observed during PHA depolymerization, enabling near-quantitative chemical
recycling to monomer. Controlled hydrogenation of the β-isopropylidene side
group produces PHAs with diverse performance metrics that are competitive with a
range of commodity polymers, spanning strong fibers to ductile thermoplastics to
superglue epoxy resins.
DOI: 10.1126/science.aed3914