Harnessing skull immunity for brain drug delivery
Summary
Therapeutic delivery to the brain after stroke is limited by the blood-brain barrier. In this issue of Cell, Gao et al. bypass this obstacle by harnessing skull bone marrow immune cells to deliver drug-loaded nanoparticles to injured brain regions, improving outcomes and revealing a feasible translational strategy for targeted CNS therapy.
Content
# Harnessing skull immunity for brain drug delivery
*Published: 2026 Mar 5*
Therapeutic delivery to the brain after stroke is limited by the blood-brain
barrier. In this issue of Cell, Gao et al. bypass this obstacle by harnessing
skull bone marrow immune cells to deliver drug-loaded nanoparticles to injured
brain regions, improving outcomes and revealing a feasible translational
strategy for targeted CNS therapy.
DOI: 10.1016/j.cell.2026.01.031