The Lancet Commission on Sepsis: transforming sepsis care and outcomes.

# Online ahead of print. *Review Article* The Lancet Commission on Sepsis: transforming sepsis care and outcomes. Shankar-Hari M(1), Ming D(2), Mendelson M(3), Rupali P(4), Adhikari NKJ(5), Ranzani O(6), Randolph A(7), Davenport E(8), van der Poll T(9), Moita LF(10), Beane A(11), Lamontagne F(12), Kwizera A(13), Holmes A(2), Diaz J(14). Author information: (1)Centre for Critical Illness Research, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London SE1 9RT, UK. Electronic address: manu.shankar-hari@kcl.ac.uk. (2)The Fleming Initiative, Imperial College London, London, UK. (3)Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa. (4)Department of Infectious Diseases, Christian Medical College, Vellore, India. (5)Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. (6)DataHealth Lab, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain. (7)Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. (8)Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. (9)Amsterdam UMC, University of Amsterdam, Center for Infection and Molecular Medicine & Division of Infectious Diseases, Amsterdam, Netherlands. (10)Center for Disease Mechanisms Research, Medicine ULisboa for Health Clinical Research and Innovation (MUHCRI), Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal. (11)Pandemic Sciences Hub and Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK. (12)Université de Sherbrooke, Sherbrooke, QC, Canada. (13)Makerere University College of Health Sciences, Kampala, Uganda. (14)Clinical Management and Operations Unit, World Health Organization, Geneva, Switzerland. DOI: 10.1016/S0140-6736(26)00648-3 PMID: 42034118 Conflict of interest statement: MS-H reports an NIHR Clinician Scientist Award (NIHR-CS-2016-16-011) from the UK National Institute for Health and Care Research (NIHR), is a member of the MRC/NIHR EME Programme, Chair of the EME-NIHR Advanced Fellowship Committee, Council of International Sepsis Forum, receives funding for his research from the NIHR, Wellcome Trust, the Medical Research Council, and Chief Scientist's Office Scotland, and has done advisory board activity through the International Sepsis Forum with payments going either into the unrestricted institutional research funds or to the International Sepsis Forum. DM reports research grants from LifeArc and NIHR. NKJA reports grants from the Canadian Institutes of Health Research (CIHR) with payments made to their institution. OR is funded by the Ramón y Cajal Programme (RYC2023-002923-C) awarded by the Spanish Ministry of Science, Innovation and Universities. AR reports grants from the US Centers for Disease Control and Prevention and National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases, receives royalties from UpToDate, consulting fees from Inotrem, honoraria for talks from ThermoFisher, reports participation on a Data Safety Monitoring Board (DSMB) for the REMAP-CAP and Prevent VILI trials, and is a Council member of the International Sepsis Forum and a Medical Advisory Board member of the Families Fighting Flu charity. ED reports Wellcome Sanger Institute core funding from the Wellcome Trust (220540/Z/20/A). TvdP reports research grants from the Ministry of Economic Affairs and Health Holland, the Dutch Thrombosis Foundation, and EU Horizon 2020 (FAIR, No 847786), consulting fees from Matisse paid to their institution, and DSMB participation for REMAP-CAP. LFM reports research grants from La Caixa Foundation (LCF/PR/HR23/52430007). AB receives partial funding from the Wellcome Innovations Flagship Collaboration for Implementation and Training in Critical Care in Asia and Africa (224048/Z/21/Z) and the NIHR DIGIPATHS Study: Digitally Integrated Care Pathways for Multiple-Long-Term-Conditions Management in Primary Care, Sri Lanka (NIHR205554). FL reports institutional research grants from CIHR, DSMB participation for the clinical trial PRESSURE, is named in a patent (PCT WO 2022/232920) for a system for controlling an administration of infused substances that is owned by his university, and is a co-fiduciary and President of OVATION Santé (Canada), a company created at his university's request as a vehicle to potentially hold or license the aforementioned patent. AK is a member of the Surviving Sepsis Campaign guidelines. AH reports research grants from NIHR Health Protection Research Unit in Healthcare Associated infection and Antimicrobial Resistance, grants from Wellcome Trust Centres for Antimicrobial Optimisation Network (CAMO-Net) via the University of Liverpool and Imperial College London, is the Director of The Fleming Initiative (a partnership between Imperial College London, Imperial College Healthcare NHS Trust, and commercial and philanthropic partners, including GSK, Cepheid, and LifeArc), is named on patents in development (three patents for diagnostic innovations related to point-of-care testing for therapeutic drug monitoring, two patents for point-of-care perinatal host factor response monitoring, and a patent on a non-invasive innovation for the application of photoplethysmography in the continuous monitoring of circulating volume in hospital settings), and is current Co-Chair of the Global Future Council (World Economic Forum) from May, 2025 to the present, a member of the WHO Health Emergencies Program (WHE) Ad-Hoc Advisory Panel of Infection Prevention and Control Experts for Preparedness, Readiness and Response to COVID-19 (WHE-IPC-AP) and the Scientific Advisory Group for Emergencies (SAGE) Coronavirus Response working group on nosocomial transmission, and was an Executive Committee member and past President of the International Society for Infectious Diseases. PR, MM, and JD declare no competing interests. The views expressed in this Comment are those of the authors and not necessarily those of the National Health Service, the NIHR, or the UK Department of Health and Social Care. MS-H is the Chair of this Commission and all other authors are Commissioners. The Centre for Critical Illness Research at King's Health Partners provides logistic and administrative support for organisation of meetings to support the work of the Commission. --- DOI: 10.1016/S0140-6736(26)00648-3