Chiral S(VI) platform unifies selective C-H amination of complex molecules and alkane feedstocks
Summary
Complex molecules and simple alkanes pose distinct challenges for catalyst-controlled carbon-hydrogen (C-H) functionalizations. Whereas densely functionalized scaffolds require precise targeting among multiple reactive sites while tolerating sensitive functionalities, unactivated substrates that lack directing groups require selective activation of exceptionally inert, nearly identical C-H bonds. In this work, we addressed both challenges by repurposing a classic chiral auxiliary into a un
Content
# Chiral S(VI) platform unifies selective C-H amination of complex molecules and alkane feedstocks
*Published: 2026 Apr 23*
Complex molecules and simple alkanes pose distinct challenges for
catalyst-controlled carbon-hydrogen (C-H) functionalizations. Whereas densely
functionalized scaffolds require precise targeting among multiple reactive sites
while tolerating sensitive functionalities, unactivated substrates that lack
directing groups require selective activation of exceptionally inert, nearly
identical C-H bonds. In this work, we addressed both challenges by repurposing a
classic chiral auxiliary into a unified, selective, and predictable C-H
amination platform mediated by silver catalysis and chiral sulfur(VI) nitrene
precursors. This system enables stereodivergent, late-stage aminations of
activated C-H bonds with broad functional group tolerance and compatibility with
aqueous conditions while also mediating mild, selective aminations of chemical
feedstocks. The sulfur(VI) motif functions as a modular, stereodefined, and
medicinally relevant synthetic linchpin for rapid library diversification,
enabling both target- and diversity-oriented synthesis.
DOI: 10.1126/science.aee3321